Multiparametric evaluation of muscle function, performance and biomarkers

Project summary

Quantitative and sensitive measure of muscle characteristics and changes after an exercise intervention can give us important knowledge about the mechanisms of altered muscle function due to exercise. This is important from a public health perspective, and for the development of specific characteristics of athletes. On long-term, such knowledge may lead better and more targeted rehabilitation of muscle function and muscular development / reconstruction after major accidents.

Biomarkers can be image-based or measured in blood samples. In this project we want to establish, evaluate and validate non- invasive biomarkers based on magnetic resonance spectroscopy ( MRS) , magnetic resonance imaging (MRI) , ultrasound and micro- RNA ( miRNA ). We aim to evaluate and compare these biomarkers with tissue samples, which is invasive and is the current measurement method to assess muscle function. Standard performance tests will be performed and will be used as a reference.