Arbeids- og kompetanseområde
Jeg er molekylærbiolog og jobber med å forstå den patologiske sammenhengen mellom genetikk og utvikling av diabetes. Jeg underviser i patologi på bioingeniørutdanningens bachelorstudie og ønsker å motivere studentene til å se sammenhengen mellom årsak og utvikling av forskjellige typer sykdom, behandling og prognose. Jeg involverer bachelor, master og phd studenter i forskningsprosjekt, der problemstilling kan være å forstå effekt av genskade på utvikling av arvelig diabetes, eller effekt av biologiske markører på prestasjon innen idrett (tverrfaglig og tverrfakultære prosjekt).
Underviser i
- Medisinsk laboratorieteknologi (BSc)
- Patologi (BSc)
- Avanserte Biomedisinske Analysemetoder (MSc/EVU)
Forskar på
- Arvelig (monogen) diabetes og genetikk
- Type 2 diabetes og genetikk
- Helse og prestasjon innen idrett
Forskargrupper
- BIOMARG
- Idrett, helse og funksjon
- BIO304, Medisinsk laboratorieteknologi IV - Avanserte laboratorieanalysar, Høst 2024
- BIO350, Bacheloroppgåve - Bioingeniør, Høst 2024
- BIO350, Bacheloroppgåve - Bioingeniør, Vår 2025
- BIO501, Kvalitetssikring av medisinske laboratorieanalysar, Høst 2024
- BIO502, Avanserte medisinske laboratorieanalysar, Vår 2025
Publikasjonar
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Acute response in circulating microRNAs following a single bout of short-sprint and heavy strength training in well-trained cyclists
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Functional characterization of HNF4A gene variants identify promoter and cell line specific transactivation effects
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Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes
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A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
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The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
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Diabetes mellitus – analyser av genvarianter assosiert med subtyper av Maturity-Onset Diabetes of the Young (MODY)
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Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants
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The Female Menstrual Cycles Effect on Strength and Power Parameters in High-Level Female Team Athletes
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Incidence of HNF1A and GCK MODY Variants in a South African Population
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Unsupervised clustering of missense variants in HNF1A using multidimensional functional data aids clinical interpretation
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Functional Analyses of HNF1A-MODY Variants Refine the Interpretation of Identified Sequence Variants
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Open online E-learning resources at epraksis.no as preparation for hands-on laboratory practice
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Functional characterization of diabetes gene variants is important for precision medicine
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E-learning facilitates flipped learning and portofolio assessment in biomedical laboratory science
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Functional characterization of HNF1A variants identified in Norwegian MODY diabetes registry can implement precision medicine in diabetes clinics
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Significance of functional studies of HNF- gene coding variants for diabetes classification
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Handballstjerna håpar ny mensenforsking kan gi svar på kva som gjekk gale
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ePraksis film om Histologisk seksjon, Patologisk avdeling (HUS)
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The E3 SUMO ligase PIAS is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1
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Functional characterization of HNF1A variants identified in Norwegian diabetes registries can be important for precision medicine in diabetes clinics
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Etbalering av mikrobiopsiteknikk på muskel (vastus lateralis)
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The E3 SUMO ligase PIASy is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1a
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A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells
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Spektrofotometri 5 - Instrumenter
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Spektrofotometri 4 - Absorpsjon _ Eksitasjon
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Spektrofotometri 3 - Kromatorer
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Spektrofotometri 2 - Absorpsjonsspektrofotometer
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Spektrofotometri 1 - Lys og foton
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Studenter var involvert i utvikling av nytt molekylærpatologisk laboratoriekurs
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The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes
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Developing high throughput assays for functional classification of novel missense variants in HNF1A
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The E3 SUMO ligase PIASy regulates the activity and stability of the transcription factor hepatocyte nuclear factor 1-alpha
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Functional characterization of all HNF4A variants in the Norwegian MODY and the Norwegian Childhood Diabetes Registries
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Muskelbiopsi - status HVL
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Functional analysis of various HNF4A variants identifies increased transactivation function of R85W causing the mutation specific phenotype of neonatal hyperinsulinism and Fanconi syndrome
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Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation
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In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
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Restriksjons enzym og analyse av DNA
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Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population
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Structure–function studies of HNF1A (MODY3) gene mutations in South Indian patients with monogenic diabetes
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DNA analyser
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Hvordan isolere og rense DNA
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Kvantitative analyser - Standard addisjon
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Kvantitative analyser - Ekstern standard
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Kvantitative analyser
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Genvarianter som risikofaktorer for diabetes
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Analysis of protein-coding genetic variation in 60,706 humans.
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The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity
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High incidence of heterozygous ABCC8 and HNF1A mutations in Czech patients with congenital hyperinsulinism
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Association of a low-frequency variant in HNF1A with type 2 diabetes in a latino population the SIGMA Type 2 Diabetes Consortium
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STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity
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GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation
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Monogenetic diabetes mellitus in Norway :
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SUMOylation of pancreatic glucokinase regulates its cellular stability and activity
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GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation
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Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE
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Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity
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Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry
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Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions
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Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation
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Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction
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A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry
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From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation
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Functional dissection of the HNF-1alpha transcription factor: A study on nuclear localization and transcriptional activation
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Molekylærgenetisk diagnostikk ved diabetes mellitus
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Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway
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Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway
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N EONATAL D IABETES M ELLITUS D UE TO C OMPLETE G LUCOKINASE D EFICIENCY
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A simple test for the hot spot mutation P291fsinsC in MODY3
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MODY associated with two novel hepatocyte nuclear factor 1 alpha loss of function mutations
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A new candidate region for the positional cloning of the XLP gene
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The interaction between human FcgammaRI and the gamma-chain is mediated solely by the 21 amino acid transmembrane domain of FcgammaRI
